Yes, I used wire on that piece as well. I have been using the Soft Flex which has a nice drape, and comes in medium, fine, and very fine. I used the fine on both strands and it worked well. I did remove a number of smaller sapphires from the first piece because their drill holes were too small for fine. They worked well on very fine, so I'm keeping that in my stash...also note, the rondelles work well with 26 gauge wire...I've incorporated "leftovers" into some tin cups for added sparkle. Overall wear of the necklace, I find it very comfortable, and no pinching or pulling of tiny hairs. Keep in mind, if you decide to do this and those sorts of pieces bother your neck, there are wonderful adapter findings that can make a 3, 4, or other multiple strand attached to a piece of chain in the back of the neck. That might also have the added advantage of making the piece adjustable. As they say, where there is a will there is a way!