That would make for an interesting setting. Stainless steel or titanium would definitely give it a masculine edge. Though a 3-inch cuff would simply overwhelm my rather skinny wrists.
At the same time, I also like the simplicity of the single pearl on leather. I do tend to prefer simpler, minimal designs. I am going to be visiting Pearl Paradise soon, and I hope to be able to find a fw or akoya pearl to make into such a bracelet.