We personally use the Vigor epoxy to make drop style "french wire" earrings. It has held up well for us. We also use it to make station necklaces on wire. Since the pearls are glued and thus aren't rubbing, there's no chance of ruining the nacre.
Drop style earrings are a really great use for full drilled pearls. We see this quite often when customers come in with a necklace they want shortened, and they wonder what to do with the extra pearls, especially when the necklace is a Tahitian or South Sea pearl necklace.
On the subject of the pearls rubbing together and being strung on wire, what do you think of Mikimoto's "Pearls In Motion" collection?
Pearls In Motion